The Potential of Low-Dose Naltrexone in Treating Depression

Naltrexone is an opiate antagonist used since 1984 in treating opiate addiction (preventing euphoric feelings) and alcoholism. During the last few years, Naltrexone used in low doses (Named  Low Dose Naltrexone) earned favor as a novel medication that may be used in depression treatment.

Major Depressive Disorder symptoms:

  1. Duration of two weeks or more.
  2. Depressed mood and lack of interest or pleasure, in addition to at least four of the following symptoms:
  • Significant weight change.
  • Sleeping disorder.
  • Slowed thinking or movement.
  • Feeling tired almost every day.
  • A feeling of worthlessness and guilt.
  • Loss of concentration.
  • Recurrent thoughts of suicide and death

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