Description
Verifiable Science
Willow bark has a long history of traditional use for musculoskeletal comfort. Several randomized human trials illustrate its actions due to salicin, a source of salicylic acid.1 Additionally, it helps to maintain healthy prostaglandin metabolism and blood flow.2 Boswellia serrata has also revealed the potential to provide statistically significant support for joint comfort.3 AKBA, or 3-acetyl-11-keto-beta-boswellic acid, may be particularly supportive in maintaining healthy 5-lipoxygenase enzyme activity and leukotriene metabolism to maintain tissue comfort.4 Curcumin maintains healthy cyclooxygenase-2 enzyme activity while supporting healthy prostaglandin, leukotriene, and thromboxane metabolism.5 Devil’s claw promotes both healthy cyclooxygenase-2 and 5-lipoxygenase enzyme activity.6 A review of 12 human studies indicates that devil’s claw may promote musculoskeletal comfort and function.7 DL-Phenylalanine supports enkephalin activity.8‡
Indications
- Ages 18 and up
- Musculoskeletal comfort and function‡
Suggested Use
As a dietary supplement, take 2 capsules, 1-3 times daily, with meals.
References
- Schmid B, et al.Phytother Res. 2001 Jun;15(4):344-50.
- Chrubasik S, et al.,em> Am J Med. 2000 Jul;109(1):9-14.
- Krishanu Sengupta, et al. Arthritis Res Ther. 2008; 10(4): R85.
- Ammon HP, et al. Planta Med. 1991 Jun;57(3):203-7.(animal)
- Zhang F, et al. Carcinogenesis. 1999 Mar;20(3):445-51.
- Loew D, et al. Clin Pharmacol Ther. 2001 May;69(5):356-64.
- Gagnier JJ, et al. BMC Complement Altern Med.2004 Sep 15;4:13.
- Russell AL, et al. Med Hypotheses. 2000 Oct;55(4):283-8.
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