Overview Of Acetyl L-Carnitine supplement
Acetyl-L-carnitine (ALC) is the derivative of the trimethylated amino acid L-carnitine (L-Carnitine burns fats into energy and transports fatty acids across the mitochondria). The ALC-transferase enzyme produces ALC in the brain, liver, and kidney.
Acetyl-L-carnitine has an advantage over L-carnitine; the ALC chemical structure can be easily absorbed in the gastrointestinal tract. Also, it crosses the blood-brain barrier (BBB) more effortlessly than regular L- Carnitine.
What are the Benefits Of Acetyl L-Carnitine supplement?
- Promotes the uptake of acetyl CoA into the mitochondria during fatty acid oxidation.
- Stimulate acetylcholine, protein, and membrane phospholipid biosynthesis.
- Obtains a cholinomimetic effect (due to the structural similarity with acetylcholine)
- Enhance energy levels.
- Decrease oxidative stress in the nervous system.
- Prevent subsequent cell death in the case of adult, neonatal, and pediatric brain injury.
- Incorporate into glutamate, glutamine, GABA, or into lipids for myelination and cell growth.
What Are the uses of Acetyl L- Carnitine supplement?
Numerous Studies have indicated that Acetyl L-Carnitine may be of benefit in Managing;
- Alzheimer’s disease (Reduce attention deficiencies in some individuals after long-term treatment, especially when combined with acetylcholinesterase inhibitors )
- Depression (Acetyl L-Carnitine supplement remarkably decrease depression symptoms)
- HIV infection (used for symptomatic management and nerve regeneration)
- Diabetic Neuropathy (Reduce pain, Enhance nerve conduction velocity, and nerve regeneration)
- Ischemia (acts as neuroprotective)
- Cognitive impairment due to alcohol abuse.
Side Effects Of Acetyl L-Carnitine supplement
Side effects are usually minor and don’t happen to all patients, some examples:
- Stomach pain
- Nausea
- Vomiting
- Diarrhea
- Dry mouth
- Headache
- Restlessness and difficulty in sleeping.
- fishy odor of the urine, breath, and sweat
- Elevated Blood Pressure
- Lower blood sugar and higher triglyceride levels (in diabetes)
- Psychosis (in bipolar disorder)
Who should not take L-Carnitine supplement?
- Pregnancy and breastfeeding: There isn’t enough reliable data. therefore, avoid using it during pregnancy or breastfeeding
- Bipolar disorder: Acetyl-L-carnitine might worsen symptoms in people with bipolar disorder who are in the remission state.
- Cancer patients treated with Taxanes: Acetyl-L-carnitine might worsen symptoms (Nerve damage in the hands and feet) in some patients using taxanes chemotherapeutic drugs.
- Hypothyroidism: There is some worry that acetyl-L-carnitine might interfere with thyroid hormone.
- Seizures: If you have ever had a seizure, don’t take acetyl-L-carnitine as there is some concern that it might increase seizure occurrence (due to the structural similarity with L-carnitine)
- In case of an allergy
L-Carnitine supplement dosage
The common dose of acetyl-l-carnitine is 1500 – 3000 milligrams/ day, taken by mouth for up to 33 months.
Does Acetyl-L-carnitine Supplement make you lose weight?
Most studies have been done on the L-carnitine form, l-carnitine supplements provide a modest reducing effect on body weight, BMI, and fat mass, especially in the case of overweight/obesity. So, it’s assumed that acetyl-L-carnitine may have a similar role because our bodies can convert L-carnitine to acetyl-L-carnitine and vice versa, but further research must be held to confirm this assumption.
Can you take Acetyl-L-carnitine Supplement every day?
Several people have been taking Acetyl-L-carnitine safely for up to 33 months. Consult your doctor, before using it for a long duration of time.
What Are The Precautions When Taking Acetyl L-Carnitine supplement?
Acetyl- L-Carnitine may interact with some medications, such as:
- Acenocoumarol (Sintrom) and Warfarin (Coumadin): they are anticoagulants and when ALC is taken with them, it might increase their effect causing bruising or even bleeding.
- Serotonergic drugs when taken with ALC might increase serotonin causing serious side effects such as heart problems, seizures, and vomiting.
- Thyroid hormone, Taking acetyl-L-carnitine with thyroid hormone might reduce the effectiveness of the treatment.
You must consult your doctor before combining Acetyl-L-Carnitine with any medication.
How Do You Get The Best Acetyl-L-Carnitine supplement Online?
Mitochondrial Support is a rich form of Acetyl-L-Carnitine and it’s capable of supplying key-mitochondrial micronutrients to the human body!
Mitochondrial Support Ingredients:
- Acetyl L-Carnitine
- N-Acetyl Cysteine
- Alpha Lipoic Acid
- Resveratrol
- Broccoli Seed Extract
- Green Tea (EGCG)
- The Micronutrient “Backbone”
Mitochondrial Support has great value because it can:
Recharges Cellular Energy Production.
Supports Immune Function.
Increases Antioxidant Protection.
Supports Detoxification Capacity.
Provides Key Micronutrients to Optimize Daily Nutritional Intake.
Includes the powerful antioxidant trio of alpha lipoic acid, N-acetyl cysteine, and acetyl L- carnitine, all shown to recharge cellular energy production and the primary cellular antioxidant pools of vitamins E and C and glutathione.
Key micronutrients and phytonutrients including green tea, broccoli seed extract, and resveratrol protect the mitochondria and continually renew the cycle of energy production.
References
- Acetyl-L-carnitine – PubMed
- Acetyl-L-Carnitine – Uses, Side Effects, And More -WebMD
- L-Carnitine and acetyl-L-carnitine roles and neuroprotection in developing brain
- Acetyl-L-Carnitine – Drugs.com
- Metabolic Syndrome and Psychiatric Illness – NUTRITIONAL SUPPLEMENTS AND METABOLIC SYNDROME -ScienceDirect
- Acetylcarnitine – ScienceDirect
- Acetyl carnitine – Drug Bank
- Acetyl-L-carnitine in HIV-associated antiretroviral toxic neuropathy-pubmed
- Effects of acetyl-L-carnitine in diabetic neuropathy and other geriatric disorders
- Effects of acetyl-L-carnitine in Alzheimer’s disease patients unresponsive to acetylcholinesterase inhibitors
- Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis
