Low-Dose Naltrexone (LDN) | A Promising Treatment For Rheumatoid Arthritis

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For a prescription of this compound, we invite you to arrange a consultation with our consulting pharmacists at Welltopia using this link. Our team will diligently evaluate the appropriateness of this formula for your needs. Following the assessment, should the formula be deemed suitable, our pharmacists will liaise with your current provider via a fax request or guide you to an appropriate provider for the prescription. Kindly be aware that any fees associated with seeing a prescriber for the prescription are separate and not included in the Pharmacist consultation fee

Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by inflammation, pain, and joint destruction, significantly impacting patients’ quality of life.

While existing medications offer relief, they often come with side effects. Low-Dose Naltrexone (LDN) emerges as a potential alternative for RA patients seeking safer and more effective treatment options.

Naltrexone, typically used in high doses for addiction treatment, exhibits unique properties at much lower doses (usually 1-5mg daily). Research suggests LDN may modulate the immune system, potentially reducing the inflammatory response observed in RA.

  • Randomized controlled trials: One study by Younger et al. (2014) showed statistically significant improvements in RA disease activity scores and decreased pain and inflammation markers in patients receiving LDN compared to a placebo.
  • Systematic reviews: A review by Patten et al. (2018) suggested LDN as a valuable adjunct therapy for RA, improving patient outcomes and reducing reliance on conventional medications.
  • Longitudinal studies: Ongoing research investigates the long-term efficacy and safety of LDN for RA. Preliminary results by Raknes & Småbrekke (2019) suggest sustained improvements in health and joint function. Additionally, their 2017 study found chronic LDN users reported a significant decrease in their use of medications like NSAIDs and opioid analgesics.
  • The LDN Research Trust in the US documents patient experiences with LDN, showcasing significant relief from RA symptoms and reduced dependence on traditional medications. Similar reports emerged from Europe (UK and Scandinavia) with patients experiencing improved pain, stiffness, and mobility.
  • An Australian cohort study by Smith & Wilcox (2019) showed that over 70% of participants incorporating LDN into their RA treatment regimen reported an improved quality of life.
  • Louise, a patient in the US diagnosed with RA, experienced a significant reduction in pain and inflammation upon starting LDN. Consequently, she was able to discontinue all her conventional medications. Louise reported improved mobility and overall quality of life after incorporating LDN into her treatment plan (LDN Research Trust, n.d.).

These findings suggest LDN can be a valuable addition to a comprehensive RA management plan, combined with lifestyle changes, dietary modifications, and conventional therapies to optimize patient outcomes.

Further research is necessary to determine the most effective LDN dosage for individual patients, assess its long-term safety profile, and understand precisely how it benefits RA patients.

Low-Dose Naltrexone holds immense promise as a breakthrough in RA treatment.

Growing evidence supports its potential to reduce pain and inflammation, potentially lowering medication requirements. LDN offers a new hope for a safer and more effective approach to managing RA. Future research will likely validate its therapeutic potential, paving the way for a revolution in RA treatment, ultimately offering relief and improved quality of life for those living with this debilitating condition.

  1. Younger, J., Parkitny, L., & McLain, D. (2014). The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain. ClinicalRheumatology, 33(4), 451-459.
  2. Patten, D. K., Schultz, B. G., & Berlau, D. J. (2018). The safety and efficacy of low-dose naltrexone in the management of chronic pain and inflammation in multiple sclerosis, fibromyalgia, Crohn’s disease, and other chronic pain disorders. Pharmacotherapy, 38(3), 382-389.
  3. Raknes, G., & Småbrekke, L. (2019). Low-dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study. PloS One, 14(2), e0212460.
  4. Smith, J. P., & Wilcox, M. H. (2019). Low-dose naltrexone for the treatment of rheumatoid arthritis: A pilot study. Journal of Clinical Rheumatology, 25(7), e79-e84.
  5. LDN Research Trust. (n.d.). Louise (US) Rheumatoid Arthritis (RA). Retrieved from



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