EFA-SIRT SUPREME

EFA-Sirt Supreme supplies a unique and highly concentrated essential fatty acid blend, providing an extremely effective relative combination of EPA, DHA, and GLA, with all-natural mixed tocopherols, specially formulated to be high in gamma (γ)-Tocopherol.

The unique composition of EFA-Sirt Supreme® provides a balance of key nutrients that current research has shown support healthy cardiovascular function.
A large amount of supportive scientific research shows that the consumption of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) omega-3 fatty acids may reduce the risk of coronary heart disease.
Omega-3 fatty acids (FA) have been shown to affect platelet aggregation, blood viscosity, plasma levels of fibrinogen, PF4, and beta-thromboglobulin and capillary flow. These effects are believed to be functions of membrane fluidity. Omega-3 fatty acids support healthy blood lipid profiles and normal healthy blood pressure, stimulate Nitric Oxide (NO), and support healthy, normal blood sugar and insulin levels. Omega-3 fatty acids help to suppress ACE, TGA beta, and SREBP and function as PPAR agonists. Additionally, omega-3 fatty acid
supplementation increases FA oxidation, which research suggests helps to decrease adipose tissue and serves to improve endothelial function.
EPA-derived eicosanoids reduce the production of pro-inflammatory eicosanoids such as LT-B4, PAF, and cytokines such as TNF-a and IL-1.
Evidence suggests that EPA must be incorporated into the cell membrane phospholipids for its beneficial effects on eicosanoid metabolism to be realized.

DHA is not only essential for neural function, but it is also an important component of cell membranes and supports normal healthy blood pressure.
DHA generally appears to improve cell membrane function via improved receptor function and signal transduction. DHA is converted by several mechanisms into docosatrienes and resolvins, which have anti-inflammatory properties. The activity may be due to the fatty acids’ effects modifying genetic expression, according to recent research.

Gamma linolenic acid (GLA), the good omega-6 fatty acid, is elongated to DGLA, the biologically active form from which eicosanoids are derived.
DGLA metabolites reduce the formation of the arachidonate-derived prostaglandins, leukotrienes, and platelet-activating factors and support normal healthy blood pressure. DGLA reduces aldosterone, sympathetic tone, and RAAS activity.
Low levels of DGLA are associated with increased cardiac risk

Gamma Tocopherol (γ-Tocopherol) Humans derive significant benefit from γ-Tocopherol, a key component of the mixed tocopherols supplied by a healthy diet high in vegetable consumption.
γ-Tocopherol has natriuretic activity, supports normal healthy glucose and insulin levels, and improves antioxidant defenses, serving as a component in minimizing cellular damage resulting from the production of radical oxygen species. Unlike alpha-tocopherol, γ-Tocopherol and its primary metabolite g-CECH, has been shown to inhibit the synthesis of PGE2.

Sirtuins and EFAs

“Sirtuins (SIRTs) deacetylate, activate, and potentiate the activity of both mitochondrial and cytoplasmic acetyl CoA synthetases (ACES-1 and ACES-2). ACES is a key enzyme that produces acetyl CoA, the key molecule generated from the breakdown of carbohydrates, lipids, and amino acids from acetate. EFAs and insulin also potentiate the activity of ACES and, thus, are additive or synergistic with SIRTs in these metabolic pathways. The EFAs, SIRTs, and insulin will, therefore, increase FA and AA synthesis, cell membrane and receptor function, increase gluconeogenesis, simulate caloric restriction, and increase life expectancy in experimental animals.”